Modified Montmorillonite as Drug Delivery Agent for Enhancing Antibiotic Therapy

The appealing properties of surfactant-intercalated Montmorillonites (Organo-montmorillonite, OMt) were successfully investigated to propose an effective drug delivery system for metronidazole (MNE) antibiotic therapy. This represents a serious pharmaceutical concern due the adverse reactions and low targeting ability MNE. non-ionic surfactant Tween 20 was used functionalize montmorillonite, thus accomplishing two-fold objective enhancing stability clay dispersion better controlling uptake release. adsorption process performed under different experimental conditions by constructing isotherms through high-performance liquid chromatography (HPLC) measurements. Powder X-ray diffraction (XRD) measurements characterize MNE/OMt compounds. gathered results revealed that occurs preferentially in interlayer, it is governed positive cooperative processes. presence drives into interlayer hampers onto external lamella faces. good performances prepared OMt controlled release MNE proved investigating profiles physiological conditions, simulating oral administration. Cytotoxicity demonstrated biocompatibility complexes evidenced that, specific nanodevices are more biocompatible than free drug.